Noninfectious uveitis in the Asia–Pacific region
نویسندگان
چکیده
منابع مشابه
Cytokine polymorphism in noninfectious uveitis.
PURPOSE Noninfectious uveitis is a sight-threatening immune-mediated intraocular inflammatory disorder. The inheritance of uveitis in multiplex families and its association with known monogenic and polygenic immunologic disorders suggests that common genetic variants underlie susceptibility to uveitis as well as to other immunologic disorders. TNFA and IL10 are strong candidate genes, given the...
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Kruh et al. set out to establish whether infliximab is safe and effective for the treatment of refractory noninfectious uveitis. They found that the drug—a monoclonal antibody used in treating several chronic inflammatory diseases—induced a high rate of complete clinical remission in recalcitrant uveitis and was well tolerated by most patients. In this retrospective, interventional, noncomparat...
متن کاملVoclosporin as a Treatment for Noninfectious Uveitis
Voclosporin is a relatively new calcineurin inhibitor that has been used successfully in humans for the treatment of plaque psoriasis. Available data indicate a good safety profile for this treatment and a significant increase in quality of life for psoriasis patients. More recently, voclosporin has been used to treat ophthalmic conditions such as uveitis. The limited data available indicate at...
متن کاملTargeting interleukin-6 for noninfectious uveitis
Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious uveitis. These uveitic conditions include Vogt-Koyanagi-Harada syndrome, uveitis associated with Behçet disease, and sarcoidosis. This review summarizes the role of IL-6 in immunity, highlighting its effect on Th17, Th1, and plasmablast differ...
متن کامل[New drugs in the treatment of noninfectious uveitis].
Uveitis is considered to cause approximately 10% of blindness in the USA. This underlies the need for new treatments for some noninfectious uveitis, as the success rate of conventional immunosuppressant treatments is low and involve important side effects. Accordingly, it is necessary to research with new drugs having a more selective action mechanism with more potency for controlling long-term...
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ژورنال
عنوان ژورنال: Eye
سال: 2018
ISSN: 0950-222X,1476-5454
DOI: 10.1038/s41433-018-0223-z